| Table of Contents | | | |||||
| Prospectus Supplement | | | |||||
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| Capitalization | | | |
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| Dilution | | | |
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| Taxation | | | |
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| Underwriting | | | |
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| Experts | | | |
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| Prospectus | | | | | | | |
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| Experts | | | |
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Phase 1a
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Phase 1a + Phase 1b
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Phase 1b only
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All pts (DL1-4)
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DL4 pts only1
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DL4/DL5 pts only(1)
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All pts (DL4/DL5)(1)
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Patients Treated
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27
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7
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12
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5
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ORR (~week 6)
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48% (13/27)
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57% (4/7)
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67% (8/12)
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80% (4/5)
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cORR (~week 12)(2)
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19% (5/27)
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29% (2/7)
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50% (6/12)*
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80% (4/5)*
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≥ Grade 3
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Adverse event
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No.
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%
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Patients with any adverse event
|
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33
|
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|
100.0
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Adverse Events of Special Interest | | | | | | | | | | | | | |
Cytokine release syndrome
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2
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6.1
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ICANS(2) | | | |
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0
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|
0.0
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Blood and lymphatic system disorders | | | | | | | | | | | | | |
Neutropenia
|
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|
27
|
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|
81.8
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Lymphopenia
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|
22
|
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|
66.7
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Leukopenia
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20
|
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60.6
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Anaemia
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17
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51.5
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Thrombocytopenia
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13
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39.4
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Cytopenia
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1
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3.0
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Leukocytosis
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1
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3.0
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Lymphocytosis
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1
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3.0
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Infections and infestations | | | | | | | | | | | | | |
Appendicitis
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1
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3.0
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COVID-19
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1
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3.0
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Enterococcal infection
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1
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3.0
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Orchitis
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1
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3.0
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Sepsis(4)(5) | | | |
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1
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3.0
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Septic shock(4)
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1
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3.0
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Respiratory, thoracic and mediastinal disorders
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Hypoxia
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2
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6.1
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Bronchial obstruction
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1
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3.0
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Laryngeal inflammation
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1
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3.0
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Pleural effusion
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1
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3.0
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Respiratory failure
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1
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3.0
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General disorders and administration site conditions
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Condition aggravated(4)
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1
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3.0
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Fatigue
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1
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3.0
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Pyrexia
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1
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3.0
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Swelling face
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1
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3.0
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Gastrointestinal disorders | | | | | | | | | | | | | |
Abdominal pain
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1
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3.0
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Diarrhoea
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1
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3.0
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Vomiting
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1
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3.0
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≥ Grade 3
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Adverse event
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No.
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%
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Investigations | | | | | | | | | | | | | |
Blood alkaline phosphatase
increased |
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1
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3.0
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Blood creatinine increased
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1
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3.0
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Blood fibrinogen decreased
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1
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3.0
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Metabolism and nutrition disorders | | | | | | | | | | | | | |
Hypokalaemia
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2
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6.1
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Failure to thrive
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1
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3.0
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Vascular disorders | | | | | | | | | | | | | |
Hypertension
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2
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6.1
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Hypotension
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1
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3.0
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Injury, poisoning and procedural complications
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Fracture
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1
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3.0
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Infusion related reaction
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1
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3.0
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Renal and urinary disorders | | | | | | | | | | | | | |
Acute kidney injury
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1
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3.0
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Proteinuria
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1
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3.0
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Cardiac disorders | | | | | | | | | | | | | |
Atrial fibrillation(3)
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1
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3.0
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Endocrine disorders | | | | | | | | | | | | | |
Inappropriate antidiuretic hormone secretion
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1
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3.0
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Eye disorders | | | | | | | | | | | | | |
Ulcerative keratitis
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1
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3.0
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Hepatobiliary disorders | | | | | | | | | | | | | |
Cholangitis
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1
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3.0
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Immune system disorders | | | | | | | | | | | | | |
Contrast media allergy
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|
1
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3.0
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Musculoskeletal and connective tissue disorders
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Muscle spasms
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1
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3.0
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Reproductive system and breast disorders
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Vaginal haemorrhage
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1
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3.0
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Skin and subcutaneous tissue disorders
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Rash maculo-papular
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1
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3.0
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As of June 30 2022
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Actual
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As adjusted
|
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(euro in thousands)
|
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Cash and cash equivalents(1)
|
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265,125
|
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Shareholders’ equity: | | | | | | | | | | | | | |
Share capital
|
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|
653
|
| | | | | | | |
Share premium
|
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|
593,026
|
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Accumulated deficit
|
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|
(466,131)
|
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|
(466,131)
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Other reserves
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|
(2,607)
|
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|
(2,607)
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Total shareholders’ equity
|
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|
124,941
|
| | | | | | | |
Total capitalization
|
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|
124,941
|
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|
Underwriter
|
| |
Number of
Ordinary Shares |
| |||
Jefferies LLC
|
| | | | | | |
SVB Securities LLC
|
| | | | | | |
Total
|
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|
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Per
Ordinary Share |
| |
Total
|
| ||||||
Public offering price
|
| | |
$
|
|
| | | |
$
|
|
| |
Underwriting discounts and commissions paid by us
|
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$
|
|
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$
|
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Proceeds to us, before expenses
|
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$
|
|
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$
|
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| Table of Contents | | | |||||
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| Experts | | | |
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Expenses
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Amount
|
| |||
SEC registration fee
|
| | |
$
|
54,550
|
| |
FINRA filing fee
|
| | |
|
75,500
|
| |
Printing and engraving expenses
|
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|
(1)
|
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Legal fees and expenses
|
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|
(1)
|
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Accounting fees and expenses
|
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|
(1)
|
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Miscellaneous costs
|
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|
(1)
|
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Total
|
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$
|
(1)
|
| |
|
|
Jefferies
|
| |
SVB Securities
|
|